REHOVOT, ISRAEL The cultivated meat company formerly known as Future Meat Technologies announced a rebranding and a change of name to Believer Meats, effective . We provide the cells with all the vital nutrients needed to grow and develop without any genetic modification. 127, 15981599 (2005). J. Tissue Eng. Abatangelo, G., Brun, P., Radice, M., Cortiro, R. & Auth, M. K. H. in Integrated Biomaterials Science (ed. Sci. Kim, H. et al. & Levenberg, S. The effect of endothelial cells on hESC-derived pancreatic progenitors in a 3D environment. Maintaining bovine satellite cells stemness through p38 pathway. 118, 32393250 (2021). Tissue Cell 19, 159166 (1987). Tissue Eng. Haraguchi, Y. et al. Li, C. H. et al. Toxicol. Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. Anim. Messmer, T. et al. Anim. Agric. PLoS ONE 6, e25661 (2011). our sites and services. Meanwhile, it received $161 million in its series B funding round in 2020, and $400 million in its latest series C round, which is the largest funding round in the cultivated meat industry to date. Chan, Y. S. et al. View all investors Compare Believer Meats to Competitors C Cultimate Foods Cultimate Foods operates as a cellular agriculture company. Headquarters: Kiryat Shmona, IsraelFounded: 2015. Front. Mol. ; Biferali, B., Proietti, D., Mozzetta, C. & Madaro, L. Fibro-adipogenic progenitors cross-talk in skeletal muscle: the social network. Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation. & McFarland, D. C. Optimization of bovine satellite cell-derived myotube formation in vitro. Establishment of myoblast cell line and identification of key genes regulating myoblast differentiation in a marine teleost, Sebastes schlegelii. Nature 456, 502506 (2008). 199, 174180 (2004). A meat company is building the world's largest facility in the US Prod. 25, 16091620 (2007). In this article, we take a look at some of the top cultured meat companies driving the shift towards sustainable food systems. Front. Okamura, L. H. et al. Kazama, T., Fujie, M., Endo, T. & Kano, K. Mature adipocyte-derived dedifferentiated fat cells can transdifferentiate into skeletal myocytes in vitro. 9, 493495 (1961). Cytotechnology 70, 14091422 (2018). See other industries within the Manufacturing sector: Aerospace Product and Parts Manufacturing , Agriculture, Construction, and Mining Machinery Manufacturing , Alumina and Aluminum Production and Processing , Animal Food Manufacturing , Animal Slaughtering and Processing , Apparel Accessories and Other Apparel Manufacturing , Apparel Knitting Mills , Architectural and Structural Metals . In vitro pre-vascularisation of tissue-engineered constructs a co-culture perspective. Dev. Front. Finally, we discuss the application of such approaches for animal-free meat production, highlighting their potential to reduce cultured meat production costs, improve the organoleptic properties of cultured meat and increase tissue thickness. Int. Bosnakovski, D. et al. Believer Meats plans to invest $123 million in a Wilson facility where it hopes to produce about 22 million pounds of meat a year. BELIEVER Meats Breaks Ground on Largest Cultivated Meat Production Facility in The World, "Our facility propels BELIEVER forward as a leader in the cultivated meat industry," says Nicole Johnson-Hoffman, CEO of BELIEVER Meats. Can a vegetarian person get a good meal at this restaurant? Believer is establishing cultivated meat as the new standard around the worldleading a bold change in how meat is produced in our global food system. In fact, in 2021, the company announced it could make almost a pound of cultivated chicken for $7.70, with a 110-gram chicken breast costing $1.70 to make. A 3D engineered scaffold for hematopoietic progenitor/stem cell co-culture in vitro. Manstein, F., Halloin, C. & Zweigerdt, R. Human pluripotent stem cell expansion in stirred tank bioreactors. Biol. The company seeks to overcome the technical challenge within the cultured meat industry of reaching scale and price parity with farmed products. Future Meat Becomes Believer Meats as it Readies for US - vegconomist Biotechnol.https://doi.org/10.3389/fbioe.2022.875069 (2022). Biol. Sci. Regen. 377, 780785 (2008). It produces its cultured meat by collecting myosatellite cells from cows and growing them in a lab, where the cells merge naturally, forming fibers that eventually grow to 800 million strands of tissue from a single sample. Tissue Eng. Archer-Daniels-Midland Company reached an agreement to acquire D.C.A. Biology https://doi.org/10.3390/biology10010006 (2021). Nat. How Believer Meats is building the future for cultivated chicken Maqsood, M. I., Matin, M. M., Bahrami, A. R. & Ghasroldasht, M. M. Immortality of cell lines: challenges and advantages of establishment. Lipsitz, Y. Y., Woodford, C., Yin, T., Hanna, J. H. & Zandstra, P. W. Modulating cell state to enhance suspension expansion of human pluripotent stem cells. Walenda, T. et al. Exp. 116, 95118 (2013). Future Meat Technologies, which does business as Believer Meats, will invest $123 million into a new 200,000 . How much funding has this organization raised over time? J. FEBS Lett. Acta Gen. Subj. Muscle-derived fibro-adipogenic progenitor cells for production of cultured bovine adipose tissue. For biotechs in particular given recent advancements in technology it has presented an opportunity to further explore lab-grown meat. This is a watershed moment for the cultivated meat industry that will allow BELIEVER Meats to meet growing demand for decades to come. Believer Meats - Facebook Drug Deliv. Believer is building a better future for people, animals and the planet with meat that is delicious, sustainable, nutritious and broadly accessible. The creation of an in vitro adipose tissue that contains a vascularadipocyte complex. For more information, visit us atbelievermeats.com. This article reviews the progress and recent achievements toward vascularization of engineered tissues, to allow long-term viability of thick 3D-engineered tissue constructs. 1 Investors Believer Meats has 1 investors. NPJ Sci. Listrat, A. et al. 3D bioprinted white adipose model for in vitro study of cancer-associated cachexia induced adipose tissue remodeling. Bioeng. 12, e1076e1087 (2018). If you are a resident of another country or region, please select the appropriate version of Tripadvisor for your country or region in the drop-down menu. 6, 2 (2018). Sci. 43, 11171129 (2021). Proc. 96, 176182 (2016). Chem. Natl Acad. Biotechnol. Proc. Behav. Sci. Cell Transpl. Biochem. Sin. Biomaterials 14, 749754 (1993). Boldrin, L. et al. It has a unique method of doing this, harnessing the advantages of tobacco plants by turning them into bioreactors to create sustainable animal-free growth factors. Nature 292, 154156 (1981). Structure, function, and regulation of desmosomes. 46, 9599 (2011). Sci. Kaji, H., Camci-Unal, G., Langer, R. & Khademhosseini, A. By pairing ADM's leading expertise in ingredient application development, and complete nutrition solutions they bring to their customers, with our groundbreaking cell-cultivation technology, with its unmatched efficiency and scalability, we aim to accelerate the development and commercialization of high-quality, safe, and delicious meat products that deliver on the increasing demands of our growing global population. Baldwin, J. et al. World Livestock 2011 Livestock in Food Security (FAO, 2011). J. Biophys. The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy. Barbucci, R.) 885945 (Kluwer, 2001). Fraeye, I., Kratka, M., Vandenburgh, H. & Thorrez, L. Sensorial and nutritional aspects of cultured meat in comparison to traditional meat: much to be inferred. Kowalczyk, A. P. & Green, K. J. A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology. & Choi, K. C. Adipose and muscle cell co-culture system: a novel in vitro tool to mimic the in vivo cellular environment. USA. Analyst Briefing Submitters are 7x more likely to receive a qualified connection. Company profile of Future Meat Technologies. Biotechnol. At. J. Sci. PeerJ 2018, e4939 (2018). Dev. Commun. 22,390 followers 4mo We're proud to announce our first U.S. production facility, located in Wilson, North Carolina. 8, 4361 (1992). 11, 171178 (2002). Anim. Biochem. Rubio, N. R., Xiang, N. & Kaplan, D. L. Plant-based and cell-based approaches to meat production. Biomaterials 25, 35833592 (2004). Natl Acad. PubMedGoogle Scholar. Nutr. Cell Biol. Ostrovidov, S. et al. Basic Clin. Reprod. Biophys. 11, 553198 (2020). & Takeuchi, S. Skeletal muscleadipose cocultured tissue fabricated using cell-laden microfibers and a hydrogel sheet. In the meantime, to ensure continued support, we are displaying the site without styles Together, we have a unique opportunity to shape the future of the protein industry and create a more sustainable food system for generations to come.. 2018, 7396905 (2018). Biochem. The company was founded in 2020 and is based in Sunchales, Argentina. https://doi.org/10.3389/fbioe.2020.00911 (2020). So far, Singapore is the only country where lab-grown meats can be legally sold, but with two recent safety approvals from the U.S. Food and Drug Administration (FDA), it looks like the U.S. could be next in line to approve the sale of cultured meat. Feyen, D. A. M. et al. Anim. Nat Rev Bioeng (2023). A 18, 14791489 (2012). FASEB J. Dakhore, S., Nayer, B. Tissue Eng. & DAmore, P. A. Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells. Exp. Rev. Exp. Believer Meats's latest funding round was a Other Investors for on . Med. USA. Meat Sci. Skeletal muscle-derived human mesenchymal stem cells: influence of different culture conditions on proliferative and myogenic capabilities. Annu. Three-dimensional co-culture of C2C12/PC12 cells improves skeletal muscle tissue formation and function. Specht, L. An Analysis of Culture Medium Costs and Production Volumes for Cultivated Meat, 130 (Good Food Institute, 2020). Les Saveurs de Sari - Tripadvisor Co-culture approaches for cultivated meat production 119, 636643 (2022). Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Tripadvisor performs checks on reviews as part of our industry-leading trust & safety standards. Wang, I.-N. E. et al. Uezumi, A. et al. & Pain, B. Ther. 10, 112 (2021). Platform for induction and maintenance of transgene-free hiPSCs resembling ground state pluripotent stem cells. Archer-Daniels-Midland Company is one of the world's leading transformers of agricultural products into food ingredients, fuels, and industrial products. Wu, Z. et al. Modulatory effects of cellcell interactions between porcine skeletal muscle satellite cells and fibroblasts on the expression of myogenesis-related genes. The company was founded in 2022 and is based in Toronto, Canada. BELIEVER is setting the standard globally to make it possible for future generations to eat and enjoy meat.". Founded in 2018 by Prof. Yaakov Nahmias, Believer's mission is to ensure that future generations can enjoy the meat we know and love. Believer is building a better future for . Application of cell co-culture system to study fat and muscle cells. 1994, 7991 (2019). Med. In 2022, it was announced that GOOD Meat signed a seven-year deal with bioprocess equipment specialist ABEC to design, manufacture, install and commission the industrys largest known bioreactors for producing avian and and mammalian cell-based meat. Ophthalmol. Three-dimensional co-culture facilitates the differentiation of embryonic stem cells into mature cardiomyocytes. Testa, S. et al. RSC Adv. Nat. Verbruggen, S., Luining, D., van Essen, A. Believer is passionate and optimistic, just like the amazing people behind the brand.". Biotechniques 64, 5258 (2018). Weizman, A., Michael, I., Wiesel-Motiuk, N., Rezania, A. Location and contact. BASILICO ET CO, Tourcoing - Restaurant Reviews, Photos - Tripadvisor The company claims that its cells are grown in patented bioreactors. A co-culture system of rat synovial stem cells and meniscus cells promotes cell proliferation and differentiation as compared to mono-culture. 115, 63696374 (2018). BELIEVER is building a better future for people, animals and the planet with meat that is delicious, sustainable, nutritious, and broadly accessible. 95, 445450 (2013). Front. Biol. BELIEVER Meats Breaks Ground on Largest Cultivated Meat Production It develops meat using a cell culture technique and focuses on climate change, food shortages, and animal welfare. & Zweigerdt, R. Up-scaling single cell-inoculated suspension culture of human embryonic stem cells. Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes. Cytotechnology 70, 503512 (2018). Believer Meats to open first US facility in North . Bovine myoblast cell production in a microcarriers-based system. Methods 10, 233237 (1986). Scheper, T. Tissue Engineering II: Basics of Tissue Engineering and Tissue Applications (eds Lee, K. & Kaplan, D.) (Springer, 2006). Sui, M. H. et al. Detailed Reviews: Reviews order informed by descriptiveness of user-identified themes such as cleanliness, atmosphere, general tips and location information. Tremolada, C., Palmieri, G. & Ricordi, C. Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine. Rep. 18, 360377 (2022). & Shimizu, T. Three-dimensional tissue fabrication system by co-culture of microalgae and animal cells for production of thicker and healthy cultured food. Bull. How our meat is made: 1. Dec 8, 2022. Once operational, the 200,000-square-foot facility will be the largest cultivated meat production center in the world with the capacity to produce at least 10,000 metric tons of cultivated meat, without the need to slaughter a single animal. Founded in 2019 by four students in the Life Sciences and Bioengineering departments of Imperial College London, Multus Biotechnology is a cultured meat company looking to develop high-performance growth media formulations at an affordable price to cultivate cells. Use of these cookies, which may be stored on your device, permits us to improve and customize your experience. Theriogenology 67, 441458 (2007). J. Mol. Biosyst. Polym. The company opened the world's first cultivated meat production line in Israel in 2021, becoming the first company to immortalize animal cells without any genetic modification and has pioneered a culture medium recycling technology that can reduce production costs and waste. Invest or Sell Believer Meats Stock - forgeglobal.com Haraguchi, Y., Okamoto, Y. J. Microbiol. Believer Meats, an Israeli biotechnology company, is building a plant in North Carolina to produce 10,000 metric tons of meat annually without ever slaughtering a single animal. Bioeng. Exp. Eat Just has a cultured meat division called GOOD Meat, which mainly focuses on growing chicken. Application of co-culture technology of epithelial type cells and mesenchymal type cells using nanopatterned structures. Regen. 6 cultured meat companies making waves Autom. Adv. Kay Sinclair, S. S. & Burg, K. J. L. Effect of osteoclast co-culture on the differentiation of human mesenchymal stem cells grown on bone graft granules. 54, 2331 (2018). 9, 2102908 (2022). J. Biosci. Textured soy protein scaffolds enable the generation of three-dimensional bovine skeletal muscle tissue for cell-based meat. Believer Meats previously named Future Meat is on a mission to make it possible for all future generations to eat meat without harming animals or the environment by using non-GMO technology which it claims enables it to achieve higher-density cell cultures and more efficient media use than other cultured meat startups. 312, 623629 (2006). 263, 361366 (2001). Haynesworth, S. E., Goshima, J., Goldberg, V. M. & Caplan, A. I. Humbird, D. Scaleup economics for cultured meat. J. Sci. With a global population expected to reach 10 billion by 2050, ADM is working with partners across the value chain to meet food security and sustainability needs by expanding the protein ecosystem, said Leticia Gonalves, ADMs president, Global Foods. A 15, 22272236 (2009). Musina, R. A., Bekchanova, E. S., Belyavskii, A. V. & Sukhikh, G. T. Differentiation potential of mesenchymal stem cells of different origin. Sci. "Members of AMPS Innovation look forward to continued advancementsin this industry to support commercialization of cultivated meat, poultry and seafood. 204, 615 (2022). Sci. 40, 632633 (2022). Hepatology 8, 10101018 (1988). It has also developed a purification method that enables cost-efficiency in the unlimited production-scale of proteins. This botanical development process could allow the company to rapidly advance its commercialization. Believer Meats top competitors are Yarzin Sella High-End Food Services, Believer Meats and SOLATO and they have annual revenue of N/A and 105 employees. Were an unmatched agricultural supply chain manager and processor, providing food security by connecting local needs with global capabilities. Lab grown culture meat will be the future of food technology Myogenic differentiation potential of mesenchymal stem cells derived from fetal bovine bone marrow. Med. Meat mainly contains muscle and fat tissue, which can be fabricated using various tissue engineering strategies, including monoculture and co-culture approaches in different scaffolds. "Today's announcement is another example of the growth, progress and increased interest in this cutting-edge industry," says Robert Rankin, Executive Director of the Association for Meat, Poultry, and Seafood Innovation (AMPS). Sci. Nishiofuku, M. et al. Its color palette uses deep blue that feels culinary and a system of supporting colors that feel fresh and vibrant. The funding will allow Multus Biotechnology to build a world-first production growth media facility in the UK. Goers, L., Freemont, P. & Polizzi, K. M. Co-culture systems and technologies: taking synthetic biology to the next level. Were blazing new trails in health and well-being as our scientists develop groundbreaking products to support healthier living. - agricultural services (78.3%): manufacturing and sale of oilseed-based products, raw materials trading, transportation, storage, etc. Physiol. Cell 126, 663676 (2006). ", "Our name change speaks to our confidence in our mission to make it possible for all future generations to eat meat. Sci. Insights from tissue engineering may advance cultured meat fabrication: in particular, co-culture approaches can promote tissue growth, differentiation and maturation. Biotechnol. Get what matters in translational research, free to your inbox weekly. Cell Stem Cell 9, 1723 (2011). These steps pave the way for cultivated meat to come to market in the U.S. at scale and helps ensure as many consumers as possible have access to these groundbreaking products," says Liz Specht, Ph.D., Vice President of Science and Technology at the Good Food Institute (GFI). 37, 10381045 (2013). 3, 46 (2019). The need and demand for sustainable, nutritious and animal-welfare-conscious meat substitutes has spurred research into cultivated meat production. Reddi, A. H. Symbiosis of biotechnology and biomaterials: applications in tissue engineering of bone and cartilage. PLoS ONE 11, e0161693 (2016). Flexible adipose-vascular tissue assembly using combinational 3D printing for volume-stable soft tissue reconstruction. ADM unlocks the power of nature to enrich the quality of life. The company was formerly known as Higher Steaks and changed its name to Uncommon in June 2023. Yousaf, M. N., Houseman, B. T. & Mrksich, M. Using electroactive substrates to pattern the attachment of two different cell populations. Lett. The company is cruelty-free and very respectful of the ecological environment. 2. The burger, made from 20,000 muscle fibers grown from cow stem cells, took three months to make and came at a cost of 250,000 ($330,000), financed by Google co-founder Sergey Brin. . Development 122, 23392348 (1996). Seki, T. Methods of induced pluripotent stem cells for clinical application. Nutr. 47, 100885 (2022). Engineering systems for the generation of patterned co-cultures for controlling cellcell interactions. Overview Financings Valuation Enterprise Value (based on primary financings) View Enterprise Value for Believer Meats. Were proud to work with a true innovator like Believer to explore new ingredients and solutions to propel the development of these exciting products, and excited to continue to add valuable partners as we work across the industry to meet growing demand driven by the enduring trends of food security and sustainability., Believer is thrilled to partner with ADM in driving innovation to expand the emerging cultivated meat industry, said Gustavo Burger, CEO of Believer. WATCH: Future Meat rebrands as Believer Meats: 'A cow needs about two & Hasegawa, K. Human pluripotent stem cell culture: Current status, challenges, and advancement. Lu, Y. et al. 13, 18831900 (1999). This brought UPSIDE Foods valuation to over $1 billion, which will help to accelerate its path to commercialization. Adipose tissue engineering for soft tissue regeneration. Stout, A. J. et al. Mater. Reviews (231) Write a review. Believer Meats, which is based in Israel, announced the location of its commercial-scale plant in the U.S. after closing its $347 million Series B funding round in late 2021. & Post, M. J. Future Meat Technologies ("Future Meat"), the industry-leading company developing innovative food technology to produce cultivated meat, has changed its name to Believer Meats ("Believer . Valamehr, B. et al. Believer states its "groundbreaking process and technology have paved the way to bring cultivated meat one step closer to commercial viability, pending US regulatory approval". 10, 1074 (2019). Believer is building a better future for people, animals and the planet with meat that is delicious, sustainable, nutritious, and broadly accessible. Lavon, N. New technologies for cultivated meat production. Believer | A Better Future For Meat Founded in 2018 by Prof. Yaakov Nahmias, Believer's mission is to ensure that future generations can enjoy the meat we know and love. 74, 3235 (2018). Meatafora company website. You're more than your latest funding, tell our customers your company's story. Believer Meats Stock Price, Funding, Valuation, Revenue & Financial Raoufi, M. F., Tajik, P., Dehghan, M. M., Eini, F. & Barin, A. Gene 802, 145869 (2021). 250, 333338 (1989). Science 276, 7174 (1997). "This important decision to build its first U.S. commercialization operation in Wilson County validates our innovative research and development and highly skilled talent while further cementing our state as the best in the nation to do business.". Believer Meats to open first US facility in North Carolina, invest $123 Biomaterials 32, 96679676 (2011). 28, 125136 (2015). Biotechnol. & Batista, M. L. Physical exercise-induced myokines and muscleadipose tissue crosstalk: a review of current knowledge and the implications for health and metabolic diseases. Physiol. Food 1, 210220 (2020). site you are consenting to these choices. 5, 927 (2022). Nature Reviews Bioengineering Google Scholar. Ed. Yuan, Z. et al. Biol. Bar-Nur, O., Russ, H. A., Efrat, S. & Benvenisty, N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Biomater. Headquarters: Berkeley, CaliforniaFounded: 2015. Perry, L., Landau, S., Flugelman, M. Y. Goulet, F., Normand, C. & Morin, O. Haug, V., Torio-Padron, N., Stark, G. B., Finkenzeller, G. & Strassburg, S. Comparison between endothelial progenitor cells and human umbilical vein endothelial cells on neovascularization in an adipogenesis mouse model. J. Mol. Development of versatile human in vitro vascularized adipose tissue model with serum-free angiogenesis and natural adipogenesis induction. & Matheny, J. G. In vitro-cultured meat production. Levy-Mishali, M., Zoldan, J. Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Sci. Believer Meats breaks ground on world's largest cultivated meat plant Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J. Mol. Pittenger, M. F. et al. Bomkamp, C. et al. Su, Y. et al. Cell 6, 13 (2014). Ben-Arye, T. et al. Today it's foodtech. What does Future Meat Technologies do? Commun. Bioeng. Stem Cell Reports 2, 366382 (2014). J. Li, Y. et al. This article reports the use of textured soy protein as a scaffold for monoculture and co-culture to create 3D engineered bovine muscle tissue. Internet Explorer). Sign up for the Nature Briefing: Translational Research newsletter top stories in biotechnology, drug discovery and pharma. 141, 147151 (2006). We harvest the fully developed animal cells and expertly prepare them to match . "We're pleased to welcome Believer Meats to North Carolina," said North Carolina Governor Roy Cooper. Differentiation 95, 2130 (2017). ALTEX 35, 464476 (2018). Rev. J. Appl. Front. 78, 76347638 (1981). Cell. 2, 17061714 (2014). Rep. 7, 41594 (2017). BELIEVER is making an initial planned investment of $123.35 million in Wilson County, located approximately 40 miles east of Raleigh, N.C., and includes plans to create over 100 new jobs over the next three years. Hayflick, L. The limited in vitro lifetime of human diploid cell strains. 18 reviews #35 of 81 Restaurants in Tourcoing $$ - $$$ Asian Thai Vietnamese. Proc. Front. Nano Lett. S2G Ventures invested in Believer Meats's Other Investors funding round. 12, 440 (2021). Int. Yin, H., Price, F. & Rudnicki, M. A. Biochim. Commun. Goodwin, J. N. & Shoulders, C. W. The future of meat: a qualitative analysis of cultured meat media coverage. Note: your question will be posted publicly on the Questions & Answers page. Perry, L., Ben-Shaul, S., Landau, S. & Levenberg, S. in Vascularization for Tissue Engineering and Regenerative Medicine (eds Holnthoner, W. et al.) Bioeng. 29, 111 (2018). Stem Cell Res. Ou, D. B. et al. Methods Mol. Cultimate Foods operates as a cellular agriculture company. For more information, visit us at believermeats.com. Cho, W. W. et al. Integrating engineered macro vessels with self-assembled capillaries in 3D implantable tissue for promoting vascular integration in-vivo. Role of osteoblastfibroblast interactions in the formation of the ligament-to-bone interface.